MW 448.9 Da, Purity >99%. Potent, cell-permeable, ATP-competitive PKC inhibitor (IC₅₀ values for PKC subtypes are 50 (α), 17 (βI), 16 (βII) and 20 nM (γ)). Inhibits PKC over other kinases (IC₅₀ values are 50 nM (MAPKAP), 100 nM (p70 S6 kinase), 2 μM (cAMP-dependent protein kinase) and 0.7 μM (phosphorylase kinase)). Crosses the blood-brain barrier.
The product is subject to the following: Abcam Restricted Use Statement